Identification and characterisation of polymorphisms in human phosphoglucomutase (PGM1)
نویسندگان
چکیده
منابع مشابه
Mapping recombination hotspots in human phosphoglucomutase (PGM1).
Human phosphoglucomutase (PGM1) is a highly poly-morphic protein. Three mutations and four intragenic recombination events between the three mutation sites generate eight protein variants including the four universally common alleles, 1+, 1 -, 2+ and 2 -, and four others that are polymorphic in some Oriental populations, 3+, 3-, 7+ and 7-. The mutations 3/7, 2/1 and +/-are in exons 1A, 4 and 8,...
متن کاملThe classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination.
The molecular basis of the classical human phosphoglucomutase 1 (PGM1) isozyme polymorphism has been established. In 1964, when this genetic polymorphism was first described, two common allelozymes PGM1 and PGM1 2 were identified by starch gel electrophoresis. The PGM1 2 isozyme showed a greater anodal electrophoretic mobility than PGM1 1. Subsequently, it was found that each of these allelozym...
متن کاملAssociation between phosphoglucomutase (PGM1) and group-specific component (Gc) subtypes and tuberculosis.
The polymorphism of PGM1 and Gc was studied by isoelectric focusing in pulmonary tuberculosis patients and controls. For the Gc system, the phenotypic frequencies did not differ significantly, but the PGM1 system showed a significant difference in the tuberculosis patients compared to controls. The data presented here show the potential of newly developed techniques to distinguish subjects with...
متن کاملUse of GFP as a Reporter for the Facile Analysis of Sequence - Specific Proteases
simple and easy way to optimize DNA singlestrand conformation polymorphism analysis. Nucleic Acids Res. 26:2245-2246. 6.Yamashita, K., T. Tatebayashi, H. Shinoda and I. Okayasu. 1996. Simplified rapid nonradioactive PCR-SSCP method applied to Kras mutation analysis. Pathol. Int. 46:801-804. 7.Yip, S.P., W. Putt, D.A. Hopkinson and D.B. Whitehouse. 1999. Identification and characterization of po...
متن کاملfunctional study of p0 proteins of two cereal yellow dwarf viruses (cydv-rpv and cydv-rps) and identification of their cellular partner
نقش سرکوبگری پروتئین p0 در دو پولروویروس کوتولگی زردی غلات cydv-rpv) و (cydv-rps، متفاوت در شدت بیماریزایی، مورد مطالعه قرار گرفت. نتایج نشان داد که هر دو پروتئین p0 p0cy-rpv) و (p0cy-rps قادر به سرکوب خاموشی آر ان ای ایجاد شده توسط ترادف های تراژن سنس و تکرار معکوس در n. benthamiana هستند. نشان داده شد که هر دو پروتئین p0 می توانند تخریب پروتئین argonaute-1 را تسهیل کنند. علاوه بر این، تمایل م...
ذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of Human Genetics
سال: 1999
ISSN: 0003-4800,1469-1809
DOI: 10.1046/j.1469-1809.1999.6320129.x